Breast cancer immunotherapy and personalized medicine

Abstract

Breast cancer response to immunotherapy is succussed; however, the evaluation of sensitive/resistant target treatment subpopulations based on stratification by tumor biomarkers may improve the predictiveness of response to immunotherapy. Treatment decisions which were based in the past predominantly on the anatomic extent of the disease are shifting to the underlying biological mechanisms. Gene array technology has led to the recognition that breast cancer is a heterogeneous disease composed of different biological subtypes, and genetic profiling enables response to chemotherapy to be predicted. Biological therapy has been developed to target HER2 receptor and combination of antibody drug conjugates linked cytotoxic therapy to HER2 antibodies. This review will give a general overview of the impact of breast cancer and the role of immunotherapy in breast cancer as well as studying tumor biomarkers that increase the likelihood of success with immunotherapy in breast cancer.