Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTcmodelling in a phase 1 study with oral rac-sotalol-Reference-Cited by-同舟云学术

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Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTcmodelling in a phase 1 study with oral rac-sotalol

Published:2014-02-21 Issue:3 Volume:77 Page:522-531
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Darpo Borje¹,Karnad Dilip R.²,Badilini Fabio³,Florian Jeff⁴,Garnett Christine E⁵,Kothari Snehal²,Panicker Gopi Krishna²,Sarapa Nenad⁶

Affiliation:

1. Karolinska Institute, Department of Clinical Sciences; Danderyd's Hospital, Division of Cardiovascular Medicine; Stockholm Sweden

2. Quintiles Cardiac Safety Services; Mumbai India

3. AMPS-LLC; New York MD USA

4. Division of Pharmacometrics; US Food and Drug Administration; Silver Spring MD USA

5. Certara; St Louis MT USA

6. Clinical Pharmacology; Hoffmann-La Roche, Inc.; Nutley NJ USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12201/fullpdf

Reference37 articles.

1. Taking the ‘idio’ out of ‘idiosyncratic’: predicting torsades de pointes;Roden;Pacing Clin Electrophysiol,1998

2. The QT interval;Bednar;Prog Cardiovasc Dis,2001

3. Gender-specific differences in the QT interval and the effect of autonomic tone and menstrual cycle in healthy adults;Burke;Am J Cardiol,1997

4. Linearly scaled, rate-invariant normal limits for QT interval: eight decades of incorrect application of power functions;Rautaharju;J Cardiovasc Electrophysiol,2002

5. Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods;Sarapa;Ann Noninvasive Electrocardiol,2004

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