The PAC-SYM questionnaire for chronic constipation: defining the minimal important difference

Author:

Yiannakou Y.1ORCID,Tack J.2,Piessevaux H.3,Dubois D.4,Quigley E. M. M.5ORCID,Ke M. Y.6,Da Silva S.7,Joseph A.8,Kerstens R.9

Affiliation:

1. County Durham and Darlington NHS Foundation Trust; Durham UK

2. Translational Research in GastroIntestinal Disorders; University of Leuven; Leuven Belgium

3. Cliniques Universitaires Saint-Luc; Université Catholique de Louvain; Brussels Belgium

4. PHARMED; Université Libre de Bruxelles; Brussels Belgium

5. Houston Methodist Hospital; Weill Cornell Medical College; Houston TX USA

6. Peking Union Medical College Hospital; Chinese Academy of Medical Science; Beijing China

7. Shire; Brussels Belgium

8. Shire; Zug Switzerland

9. Orion Statistical Consulting BV; Hilvarenbeek the Netherlands

Funder

Shire International GmbH, Zug, Switzerland

Shire

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference36 articles.

1. Systematic review: impact of constipation on quality of life in adults and children;Belsey;Aliment Pharmacol Ther,2010

2. Psychometric validation of a constipation symptom assessment questionnaire;Frank;Scand J Gastroenterol,1999

3. Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial;Johanson;Clin Gastroenterol Hepatol,2004

4. A randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation;Lin;World J Gastroenterol,2007

5. Stepped treatment of older adults on laxatives. The STOOL trial;Mihaylov;Health Technol Assess,2008

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