Intralesional methotrexate in the treatment of localized vitiligo: A pilot study

Author:

Elrewiny Emad M.1,Shawky Ahmed1,Mohamed Sameh Fawzy Fahmy1,Ammar Amr Mohammad1,Mansour Mofreh2,Rageh Mahmoud A.1ORCID

Affiliation:

1. Department of Dermatology, Faculty of Medicine Al‐Azhar University Cairo Egypt

2. Department of Dermatology, Faculty of Medicine Al‐Azhar University Assiut Egypt

Abstract

AbstractBackground/ObjectivesVitiligo is an immune‐mediated skin disorder that targets epidermal melanocytes leading to the appearance of depigmented skin patches. Different treatment modalities have been reported with varied efficacy. We tried to evaluate the safety and efficacy of intralesional methotrexate in treating localized areas of vitiligo.MethodsThirty participants with localized patches of vitiligo were recruited. They were treated with intralesional injections of methotrexate every 2 weeks for a maximum of six sessions. At the end of the study, the degree of repigmentation was categorized into: excellent improvement (>75% repigmentation), good improvement (50%–75% repigmentation), fair improvement (25%–50% repigmentation) and poor improvement (<25% repigmentation).ResultsWe included 7 males (23.3%) and 23 females (76.7%). Their mean age was 33.6 ± 8.6 years. The duration of the disease ranged from 1 to 22 years. Four patients had a family history of vitiligo. At the end of the study, there was a highly statistically significant improvement (p < 0.001) after treatment regarding repigmentation.ConclusionsThis study showed that intralesional methotrexate is a safe and effective treatment option for patients with localized vitiligo lesions. Further studies on a larger scale are needed to evaluate the long‐term effects of treatment and detect the ideal dose to be injected.

Publisher

Wiley

Subject

Dermatology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Role of Cytokines and Chemokines in Vitiligo and Their Therapeutic Implications;Journal of Clinical Medicine;2024-08-20

2. Quoi de neuf en dermatologie interventionnelle ?;Annales de Dermatologie et de Vénéréologie - FMC;2023-12

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