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Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis

  • Published:2017-07-07 Issue:15 Volume:284 Page:2501-2512
  • ISSN:1742-464X
  • Container-title:The FEBS Journal
  • language:en
  • Short-container-title:FEBS J

Author:

Wang Yizhou1,van Assen Aart H.G.1,Reis Carlos R.1,Setroikromo Rita1,van Merkerk Ronald1,Boersma Ykelien L.1,Cool Robbert H.1,Quax Wim J.1

Affiliation:

1. Department of Chemical and Pharmaceutical Biology; Groningen Research Institute of Pharmacy; University of Groningen; The Netherlands

Funder

Department of Pathology and Medical Biology

Universitair Medisch Centrum Groningen

Dutch Top Institute Pharma project TNF-ligands in cancer

China Scholarship Council

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

1. Signaling pathways in osteoclast differentiation;Kim;Chonnam Med J,2016

2. Biology of RANK, RANKL, and osteoprotegerin;Boyce;Arthritis Res Ther,2007

3. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system;Tanaka;Immunol Rev,2005

4. RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor;Nelson;Structure,2012

5. Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss;Trouvin;Clin Interv Aging,2010

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