Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial

Author:

Oliver‐Pons Carla12,Sala‐Vila Aleix34,Cofán Montserrat12,Serra‐Mir Mercè12,Roth Irene12,Valls‐Pedret Cinta12,Domènech Mònica12,Ortega Emilio124,Rajaram Sujatha5,Sabaté Joan5,Ros Emilio124,Chiva‐Blanch Gemma1246ORCID

Affiliation:

1. Lipid Clinic, Endocrinology and Nutrition Department Hospital Clínic Barcelona Spain

2. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain

3. Hospital del Mar Research Institute Barcelona Spain

4. Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III (ISCIII) Madrid Spain

5. Center for Nutrition, Healthy Lifestyle and Disease Prevention, School of Public Health Loma Linda University Loma Linda California USA

6. Health Sciences Faculty Universitat Oberta de Catalunya (UOC) Barcelona Spain

Abstract

AbstractBackgroundNutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha‐linolenic (the vegetable n‐3 fatty acid) and polyphenols, their regular consumption might be a dietary option to reduce age‐related bone loss. We determined whether daily walnut consumption improves bone mineral density (BMD) and circulating biomarkers of bone turnover.MethodsThe Walnuts and Healthy Aging study (WAHA) is a two‐center, parallel, randomized controlled trial evaluating the effect of a diet enriched with walnuts at ≈15% energy compared with a control diet for 2 years on age‐related health outcomes in healthy men and women aged 63–79 years. Changes in BMD were a prespecified secondary outcome only at the Barcelona node of the trial, where 352 participants were randomized. Retention rate was 92.6%. Primary endpoints were 2‐year changes in BMD at the spine and the nondominant femoral neck, determined by dual‐energy X‐ray absorptiometry (DXA). Secondary endpoints were 2‐year changes in bone turnover biomarkers (adrenocorticotropic hormone, Dickkopf WNT signaling pathway inhibitor‐1, osteoprotegerin, osteocalcin, osteopontin, sclerostin, parathyroid hormone, and fibroblast growth factor‐23), which were quantified in 211 randomly selected participants.ResultsThe walnut diet versus the control diet had no effect on 2‐year changes in BMD at the spine (0.15% vs. 0.35%, p = 0.632) and femoral neck (−0.90% vs. −0.70%, p = 0.653), or on bone turnover biomarkers. Results were similar in participants treated or not with bone resorption inhibitors or those with or without osteoporosis/osteopenia at inclusion.ConclusionsCompared with the usual diet, a diet enriched with walnuts at 15% of energy for 2 years failed to improve BMD or circulating markers of bone metabolism in healthy older people.

Funder

California Walnut Commission

Nutricia Research Foundation

Publisher

Wiley

Reference37 articles.

1. Population ages 65 and above (% of total population) [cited 2023 Oct 18]. Available from:https://data.worldbank.org/indicator/SP.POP.65UP.TO.ZS

2. From Lifespan to Healthspan

3. Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

4. Nutritional intake and bone health

5. Nutrients and Dietary Patterns Related to Osteoporosis

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3