Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin-Reference-Cited by-同舟云学术

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Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin

Published:2017-05-11 Issue:6 Volume:15 Page:1213-1222
ISSN:1538-7933
Container-title:Journal of Thrombosis and Haemostasis
language:en
Short-container-title:J Thromb Haemost

Author:

Pehrsson S.¹,Johansson K. J¹,Janefeldt A.¹,Sandinge A.-S.¹,Maqbool S.²,Goodman J.²,Sanchez J.¹,Almquist J.¹³⁴,Gennemark P.¹,Nylander S.¹

Affiliation:

1. Cardiovascular and Metabolic Diseases; Innovative Medicines and Early Development; AstraZeneca; Mölndal Sweden

2. Clinical Pharmacology and DMPK; MedImmune; Cambridge UK

3. Fraunhofer-Chalmers Center; Chalmers Science Park; Gothenburg Sweden

4. Systems and Synthetic Biology; Department of Biology and Biological Engineering; Chalmers University of Technology; Gothenburg Sweden

Funder

AstraZeneca

MedImmune

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.13680/fullpdf

Reference23 articles.

1. Preclinical and clinical studies with selective reversible direct P2Y12 antagonists;Van Giezen;Semin Thromb Hemost,2005

2. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes;Storey;J Am Coll Cardiol,2007

3. Effects of P2Y(12) receptor antagonists beyond platelet inhibition - comparison of ticagrelor with thienopyridines;Nylander;Br J Pharmacol,2016

4. Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1;Armstrong;J Cardiovasc Pharmacol Ther,2014

5. Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance;Cattaneo;J Am Coll Cardiol,2014

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4. Reversal and removal of oral antithrombotic drugs in patients with active or perceived imminent bleeding;European Heart Journal;2023-03-29

5. Platelet function testing using the Multiplate analyzer after administration of aspirin in Aachen minipigs;PLOS ONE;2022-10-18

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