AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation-Reference-Cited by-同舟云学术

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AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation

Published:2015-01-12 Issue:5 Volume:172 Page:1292-1304
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Feuerbach Dominik¹,Pezous Nicole¹,Weiss Markus¹,Shakeri-Nejad Kasra¹,Lingenhoehl Kurt¹,Hoyer Daniel²,Hurth Konstanze¹,Bilbe Graeme³,Pryce Christopher R⁴,McAllister Kevin¹,Chaperon Frederique⁵,Kucher Klaus⁵,Johns Donald⁵,Blaettler Thomas⁶,Lopez Lopez Cristina⁵

Affiliation:

1. Novartis Institutes for BioMedical Research; Basel Switzerland

2. Department of Pharmacology and Therapeutics; University of Melbourne; Victoria Australia

3. DNDi - Drugs for Neglected Diseases initiative; Geneva Switzerland

4. Department of Psychiatry, Psychotherapy and Psychosomatics; Zurich University Hospital for Psychiatry; Zurich Switzerland

5. Translational Medicine Neurosciences; Novartis Pharma AG; Basel Switzerland

6. F Hoffmann-La Roche Ltd.; Basel Switzerland

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13001/fullpdf

Reference44 articles.

1. The Concise Guide to PHARMACOLOGY 2013/14: Ligand-gated ion channels;Alexander;Br J Pharmacol,2013

2. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21;Arendash;Brain Res,1995

3. Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: a novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia;Bitner;Alzheimers Dement,2013

4. In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease;Bitner;J Pharmacol Exp Ther,2010

5. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile;Biton;Neuropsychopharmacology,2007

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