Renal safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus

Author:

Desai Mehul1ORCID,Yavin Yshai1,Balis Dainius1,Sun Don1,Xie John1,Canovatchel William1,Rosenthal Norm1

Affiliation:

1. Janssen Research & Development, LLC; Raritan New Jersey

Funder

Janssen Research & Development, LLC

Janssen Global Services, LLC

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference17 articles.

1. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia;DeFronzo;Diabetes Obes Metab,2012

2. Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes: cardiovascular and kidney effects, potential mechanisms and clinical applications;Heerspink;Circulation,2016

3. Chronic renal diseases: renoprotective benefits of renin-angiotensin system inhibition;Remuzzi;Ann Intern Med,2002

4. US Food and Drug Administration Canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR): drug safety communication - strengthened kidney warnings http://www.fda.gov/Safety/Medwatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm506554.htm

5. Ridgefield, CT Boehringer Ingelheim Pharmaceuticals, Inc. 2015

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