Australian consensus: Treatment goals for moderate to severe psoriasis in the era of targeted therapies – Considerations for paediatric patients

Author:

Foley Peter123ORCID,Mahar Patrick D.134ORCID,Smith Saxon D.56ORCID,Gupta Monisha78910ORCID,Manuelpillai Nicholas2ORCID,Orchard David411ORCID,Wong Li‐Chuen121314ORCID,Su John C.341516ORCID,James Amelia17ORCID,Fischer Gayle1418ORCID,Marshman Gillian192021ORCID,Rawlin Morton22ORCID,Turner Murray23ORCID,King Emma4ORCID,Kennedy Robyn4ORCID,Baker Christopher123ORCID

Affiliation:

1. Skin Health Institute Carlton Victoria Australia

2. Department of Dermatology St Vincent's Hospital Melbourne Fitzroy Victoria Australia

3. The University of Melbourne Melbourne Victoria Australia

4. Department of Dermatology The Royal Children's Hospital Parkville Victoria Australia

5. Sydney Adventist Hospital Clinical School, ANU College of Health and Medicine The Australian National University Canberra Australian Capital Territory Australia

6. The Dermatology and Skin Cancer Centre St Leonards New South Wales Australia

7. Department of Dermatology Liverpool Hospital Liverpool New South Wales Australia

8. The Skin Hospital Westmead New South Wales Australia

9. The University of New South Wales Sydney New South Wales Australia

10. Western Sydney University Sydney New South Wales Australia

11. Barkers Road Dermatology Kew Victoria Australia

12. Royal Prince Alfred Hospital Medical Centre Newtown New South Wales Australia

13. Department of Dermatology Children's Hospital Westmead New South Wales Australia

14. The University of Sydney Camperdown New South Wales Australia

15. Eastern Health Melbourne Victoria Australia

16. Murdoch Children's Research Institute Parkville Victoria Australia

17. Department of Dermatology The Alfred Hospital Melbourne Victoria Australia

18. Department of Dermatology Royal North Shore Hospital St Leonards New South Wales Australia

19. Dermatology Clinic Flinders Medical Centre Adelaide South Australia Australia

20. Willan House Dermatology Brighton South Australia Australia

21. College of Medicine and Public Health Flinders University Bedford Park South Australia Australia

22. Macedon Medical Centre Templestowe Lower Victoria Australia

23. Psoriasis Australia Carlton Victoria Australia

Abstract

AbstractBackgroundTreatment goals have been established in Australia to facilitate the management of adults with moderate to severe psoriasis. The Australasian College of Dermatologists sought to determine if and how these adult treatment goals could be modified to accommodate the needs of paediatric and adolescent patients.MethodsA modified Delphi approach was used. Comprehensive literature review and guideline evaluation resulted in the development of statements and other questions to establish current clinical practices. Two rounds of anonymous voting were undertaken, with a collaborative meeting held in between to discuss areas of discordance. Overall, consensus was defined as achievement of ≥75% agreement in the range 7–9 on a 9‐point scale (1 strongly disagree; 9 strongly agree).ResultsConsensus was achieved on 23/29 statements in round 1 and 17/18 statements in round 2. There was a high level of concordance with treatment criteria in the adult setting. The limitations of applying assessment tools developed for use in adult patients to the paediatric setting were highlighted. Treatment targets in the paediatric setting should include objective metrics for disease severity and psychological impact on the patients and their family, and be based on validated, age‐appropriate tools.ConclusionWhile the assessment, classification and management of moderate to severe psoriasis in paediatric patients aligns with metrics established for adults, it is vital that nuances in the transition from childhood to adolescence be taken into account. Future research should focus on psoriasis severity assessment scales specific to the paediatric setting.

Funder

Janssen Pharmaceutica

Publisher

Wiley

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