STAT3 and REDD1: an unconventional story of gene repression

Abstract

The non‐canonical functions of the transcription factor STAT3 have been poorly studied in comparison to its canonical mechanisms of gene expression activation. Here, Köhler et al. put the spotlight on a novel unconventional repressing mechanism of STAT3 over the REDD1 gene, named DDIT4. These findings are crucial to expand the knowledge of the stress‐induced short‐lived REDD1 protein that inactivates mTOR and the consequences of this fine‐tuned regulation in the context of pathological conditions such as cancer or neurodegenerative diseases.