Affiliation:
1. CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology Chinese Academy of Sciences Beijing China
2. State Key Laboratory of Genetic Engineering, School of Life Sciences Fudan University Shanghai China
Abstract
Mammals have potent innate immune systems that work together to fight against a variety of distinct viruses. In addition to interferon (IFN) response, which has been intensively studied, antiviral RNA interference (RNAi) is gradually being studied. However, previous studies indicated low Dicer activity on double‐stranded RNA (dsRNA) substrates in vitro and that IFN response masks or inhibits antiviral RNAi in mammals. Therefore, whether or not the RNAi is functional for antiviral response in mammalian somatic cells is still an ongoing area of research. In this review, we will present the current advances in antiviral RNAi in mammals and focus on three fundamental questions critical to the intense debate about whether RNAi can function as an innate antiviral immunity in mammals.
Funder
National Natural Science Foundation of China
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
1 articles.
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