Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1receptor internalization

Author:

Sykes David A1,Riddy Darren M1,Stamp Craig1,Bradley Michelle E1,McGuiness Neil1,Sattikar Afrah1,Guerini Danilo2,Rodrigues Ines2,Glaenzel Albrecht2,Dowling Mark R1,Mullershausen Florian2,Charlton Steven J1

Affiliation:

1. Novartis Institutes for Biomedical Research; Horsham West Sussex UK

2. Novartis Institutes for Biomedical Research; Basel Switzerland

Publisher

Wiley

Subject

Pharmacology

Reference26 articles.

1. The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors;Alexander;Br J Pharmacol,2013

2. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity;Bandhuvula;J Biol Chem,2005

3. The in vitro metabolism of sphingosine-1-phosphate: identification, inhibition and pharmacological implications;Bradley;Eur J Pharmacol,2011

4. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis;Brinkmann;Nat Rev Drug Discov,2010

5. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus;Chiba;Cell Mol Immunol,2006

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