Healthcare professionals' and consumers' knowledge, attitudes, perspectives, and education needs in oncology pharmacogenomics: A systematic review

Author:

Lim Chiao Xin1ORCID,Bozkurt Alistair1,Chen Zi Yue1,Hird Abbey1,Wickens Joanne1,Lazarakis Smaro2ORCID,Hussainy Safeera Y.345ORCID,Alexander Marliese34ORCID

Affiliation:

1. Pharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria Australia

2. Health Sciences Library, Royal Melbourne Hospital Parkville Victoria Australia

3. Pharmacy Department, Peter MacCallum Cancer Centre Melbourne Victoria Australia

4. Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria Australia

5. Department of General Practice, School of Public Health and Preventive Medicine Monash University Clayton Victoria Australia

Abstract

AbstractClinical implementation of pharmacogenomic (PGx)‐guided prescribing in oncology lags behind research evidence generation. We aimed to identify healthcare professionals' (HCPs) and consumers' knowledge, attitudes, perspectives, and education needs to inform strategies for implementation of scalable and sustainable oncology PGx programs. Systematic review of original articles indexed in EMBASE, EMCARE, MEDLINE, and PsycInfo from January 2012 until June 2022, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and using the Mixed Methods Appraisal Tool. PROSPERO registration number CRD42022352348. Of 1442 identified studies; 23 met inclusion criteria with 87% assessed high quality. Of these, 52% reported on HCPs, 35% on consumers, and 13% on both HCPs and consumers. Most were conducted in the United States (70%) and included multiple cancer types (74%). Across studies, HCPs and consumers mostly perceived value in PGx, however, both groups reported barriers to utilization, including cost, lack of consistent recommendations across guidelines, and limited knowledge among HCPs; test accuracy, clear testing benefits, and genomic information confidentiality among consumers. HCPs and consumers value and want to engage in PGx strategies in oncology care, however, are inhibited by unmet needs and practice and knowledge gaps. Implementation strategies aimed at addressing these issues may best support increased PGx uptake in oncology practice.

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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