Inter-study variability of preclinicalin vivosafety studies and translational exposure-QTc relationships - a PKPD meta-analysis-Reference-Cited by-同舟云学术

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Inter-study variability of preclinicalin vivosafety studies and translational exposure-QTc relationships - a PKPD meta-analysis

Published:2015-07-21 Issue:17 Volume:172 Page:4364-4379
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Gotta V¹,Cools F²,van Ammel K²,Gallacher D J²,Visser S A G³,Sannajust F⁴,Morissette P⁴,Danhof M¹,van der Graaf P H¹

Affiliation:

1. Systems Pharmacology; Leiden Academic Center of Drug Research (LACDR); Leiden University; Leiden The Netherlands

2. Global Safety Pharmacology; Janssen Research & Development; Janssen Pharmaceutica NV; Beerse Belgium

3. Quantitative Pharmacology and Pharmacometrics/Merck Research Laboratories; Merck & Co., Inc.; Upper Gwynedd PA USA

4. SALAR-Safety and Exploratory Pharmacology Department/Merck Research Laboratories; Merck & Co., Inc.; Westpoint PA USA

Funder

Dutch Top Institute Pharma (TIPharma)

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13218/fullpdf

Reference41 articles.

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2. Review of the statistical analysis of the dog telemetry study;Aylott;Pharm Stat,2010

3. Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects;Barbey;Clin Pharmacol Ther,1999

4. Bonate PL 2011 The art of modeling Pharmacokintic-Pharmacodynamic Modeling and Simulation (Springer Science) 55

5. Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making;Carlsson;AAPS J.,2009

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