Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

Author:

Yi Bitna1,Sahn James J.2,Ardestani Pooneh Memar1,Evans Andrew K.1,Scott Luisa L.3,Chan Jessica Z.2,Iyer Sangeetha3,Crisp Ashley3,Zuniga Gabriella3,Pierce Jonathan T.3,Martin Stephen F.2,Shamloo Mehrdad1

Affiliation:

1. Department of Neurosurgery; Stanford University School of Medicine; Palo Alto California USA

2. Department of Chemistry; The University of Texas at Austin; Austin Texas USA

3. Waggoner Center for Alcohol and Addiction Research; Institute of Neuroscience; Center for Learning and Memory; Center for Brain, Behavior and Evolution and Department of Neuroscience; The University of Texas at Austin; Austin Texas USA

Funder

NIH Office of Research Infrastructure Programs

National Institutes of Health

Robert A. Welch Foundation

Alzheimer's Association, and Lumind Research Foundation

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

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