Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa

Author:

Maag Anja12ORCID,van Rein Nienke234ORCID,Schuijt Tim J.5,Kopatz Wil F.6,Kruijswijk Danielle1,Thomassen Stella7,Hackeng Tilman M.7,Camire Rodney M.89,van der Poll Tom1,Meijers Joost C. M.610ORCID,Bos Mettine H. A.2,van ’t Veer Cornelis1

Affiliation:

1. Center for Experimental and Molecular Medicine Amsterdam Infection and Immunity Institute, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands

2. Division of Thrombosis and Hemostasis Leiden University Medical Center Leiden the Netherlands

3. Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands

4. Department of Clinical Pharmacy and Toxicology Leiden University Medical Center Leiden the Netherlands

5. Clinical Chemistry and Hematology Laboratory Hospital Gelderse Vallei Ede Ede the Netherlands

6. Department of Experimental Vascular Medicine Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands

7. Department of Biochemistry Cardiovascular Research Institute Maastricht Maastricht University Maastricht the Netherlands

8. Division of Hematology and the Perelman Center for Cellular and Molecular Therapeutics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA

9. Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

10. Department of Molecular and Cellular Hemostasis Sanquin Research Amsterdam the Netherlands

Funder

Trombosestichting Nederland

National Institutes of Health

Publisher

Wiley

Subject

Hematology

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