Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

Author:

Dong Yushu1,Fan Chongxi23,Hu Wei2,Jiang Shuai4,Ma Zhiqiang3,Yan Xiaolong3,Deng Chao5,Di Shouyin3,Xin Zhenlong2,Wu Guiling2,Yang Yang2,Reiter Russel J.6,Liang Guobiao1

Affiliation:

1. Department of Neurosurgery; General Hospital of Shenyang Military Area Command; Shenyang China

2. Department of Biomedical Engineering; The Fourth Military Medical University; Xi'an China

3. Department of Thoracic Surgery; Tangdu Hospital; The Fourth Military Medical University; Xi'an China

4. Department of Aerospace Medicine; The Fourth Military Medical University; Xi'an China

5. Department of Cardiovascular Surgery; Xijing Hospital; The Fourth Military Medical University; Xi'an China

6. Department of Cellular and Structural Biology; UT Health Science Center; San Antonio TX USA

Funder

National Natural Science Foundation of China

Medical Science Youth Breeding Project of Chinese People's Liberation Army

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Endocrinology

Reference56 articles.

1. Delayed neurological deterioration after subarachnoid haemorrhage;Macdonald;Nat Rev Neurol,2014

2. Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage;Chen;J Pineal Res,2014

3. Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway;Wang;J Pineal Res,2013

4. Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice;Yang;J Pineal Res,2015

5. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury;Yang;J Pineal Res,2013

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