Clinical utiliy of a model‐based piperacillin dose in neonates with early‐onset sepsis

Author:

Wu Yue‐E1,Hou Shan‐Shan23,Fang Zeng‐Yu4,Tang Bo‐Hao1,Yao Bu‐Fan1,Dong Yi‐Ning1,Li Xue1,Shi Hai‐Yan5,Zheng Yi1,Hao Guo‐Xiang1,Huang Xin5,Van Den Anker John678,Yu Yong‐Hui24,Zhao Wei15ORCID

Affiliation:

1. Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University Jinan Shandong China

2. Department of Neonatology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong China

3. Department of Pediatrics Yantai Yuhuangding Hospital Yantai Shandong China

4. Department of Neonatology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China

5. Department of Pharmacy, Clinical Trial Center, Shandong Provincial Qianfoshan Hospital The First Affiliated Hospital of Shandong First Medical University Jinan Shandong China

6. Division of Clinical Pharmacology Children's National Medical Center Washington DC USA

7. Departments of Pediatrics, Pharmacology & Physiology George Washington University, School of Medicine and Health Sciences Washington DC USA

8. Department of Paediatric Pharmacology and Pharmacometrics University Children's Hospital Basel Basel Switzerland

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference40 articles.

1. Neonatal sepsis—many blood samples, few positive cultures: implications for improving antibiotic prescribing;Blackburn RM;Arch Dis Child Fetal Neonatal Ed,2012

2. Reduction of unnecessary antibiotic therapy in newborn infants using interleukin‐8 and C‐reactive protein as markers of bacterial infections;Franz AR;Pediatrics,1999

3. The use of laboratory biomarkers for surveillance, diagnosis and prediction of clinical outcomes in neonatal sepsis and necrotising enterocolitis;Ng PC;Arch Dis Child Fetal Neonatal Ed,2015

4. Patterns of empiric antibiotic administration for presumed early‐onset neonatal sepsis in neonatal intensive care units in the United States;Oliver EA;Am J Perinatol,2017

5. Early‐onset sepsis among preterm neonates in China, 2015 to 2018;Jiang S;Pediatr Infect Dis J,2019

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