Dosing regimen optimisation for oseltamivir in immunocompromised paediatric patients with influenza: Extrapolation of efficacy

Author:

Jordie Eric Burroughs1ORCID,Gibiansky Leonid2,Knab Timothy1,Lemenuel‐Diot Annabelle3,Ravva Patanjali4,Zwanziger Elke3,Jolivet Sebastien3,Bhardwaj Rajinder5,Hernández‐Sánchez Jules6,Nasmyth‐Miller Clare6,Sturm Stefan3

Affiliation:

1. Translational & Systems Pharmacology Metrum Research Group LLC Tariffville CT USA

2. QuantPharm LLC North Potomac MD USA

3. Roche Innovation Center Basel Roche Pharmaceutical Research and Early Development Basel Switzerland

4. Roche Innovation Center New York Roche Pharmaceutical Research and Early Development New York NY USA

5. Integrated Drug Development Certara Strategic Consulting Parsippany NJ USA

6. Roche Products Limited Product Development Welwyn Garden City UK

Funder

Roche

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference33 articles.

1. Neuraminidase Inhibitors for Influenza

2. Tamiflu® US Prescribing Information.https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021087s068 021246s051lbl.pdf. Accessed February 2 2021.

3. Roche Pharmaceuticals.Tamiflu® (oseltamivir) summary of product characteristics.https://www.ema.europa.eu/en/documents/product-information/tamiflu-epar-product-information_en.pdf. Accessed February 2 2021.

4. Safety, Resistance, and Efficacy Results from a Phase IIIb Study of Conventional- and Double-Dose Oseltamivir Regimens for Treatment of Influenza in Immunocompromised Patients

5. Recovery of Drug‐Resistant Influenza Virus from Immunocompromised Patients: A Case Series

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