Plasma sCD146 is a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease

Author:

Jia Xinyu1ORCID,Jiang Jingxian1ORCID,Yang Chen2,Zhang Sujuan3ORCID,Wu Jingjing1ORCID,Ma Qiyun14ORCID,Wang Zhengxia1ORCID,Chen Zhongqi1ORCID,Zhang Mingshun2ORCID,Huang Mao1ORCID,Ji Ningfei1ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing China

2. Department of Immunology, Jiangsu Province Engineering Research Center of Antibody Drug, NHC Key Laboratory of Antibody Technique Nanjing Medical University Nanjing China

3. Department of Respiratory and Critical Care Medicine The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University Changzhou China

4. Department of Respiratory and Critical Care Medicine The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University Huaian China

Abstract

AbstractThis study examined the levels of soluble CD146 (sCD146) in plasma samples from patients with chronic obstructive pulmonary disease (COPD) and assessed the relationship between sCD146 and the severity of COPD. A total of 97 COPD patients were recruited from 20 medical centers in Jiangsu, China, including 13 stable subjects and 84 exacerbated subjects. The plasma sCD146 level in exacerbated subjects (28.77 ± 10.80 ng/mL) was significantly lower than that in stable subjects (38.84 ± 15.00 ng/mL). In the high sCD146 group, the proportion of subjects with modified Medical Research Council (mMRC) scores of 0–1 was higher, the proportion of subjects with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 4 was lower, and the proportion of subjects with ≥1 hospitalizations in the past year was lower. The plasma sCD146 level was negatively correlated with the COPD Assessment Test (CAT) score (r = −0.2664, p = 0.0087). Logistic regression analysis showed that sCD146 was an independent risk factor for acute exacerbation of COPD (AECOPD). Receiver operating characteristic (ROC) analysis suggested that sCD146 combined with sex, age, pulmonary function, and acute exacerbations in the past year had clinical value for the accurate identification of AECOPD, with an area under the ROC curve (AUC) of 0.908 (95% CI: 0.810–1.000, p < 0.001). In addition, there was a significant negative correlation between plasma sCD146 and S100A9 (r = −0.3939, p < 0.001).

Publisher

Wiley

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