Cerebral Cortical Microvascular Rarefaction in Metabolic Syndrome is Dependent on Insulin Resistance and Loss of Nitric Oxide Bioavailability

Author:

Chantler Paul D.123,Shrader Carl D.234,Tabone Lawrence E.125,d'Audiffret Alexandre C.136,Huseynova Khumara136,Brooks Steven D.36,Branyan Kayla W.13,Grogg Kristin A.3,Frisbee Jefferson C.237

Affiliation:

1. Division of Exercise Physiology; West Virginia University Health Sciences Center; Morgantown West Virginia USA

2. Clinical and Translational Sciences Institute; West Virginia University Health Sciences Center; Morgantown West Virginia USA

3. Center for Cardiovascular and Respiratory Sciences; West Virginia University Health Sciences Center; Morgantown West Virginia USA

4. Department of Family Medicine; West Virginia University Health Sciences Center; Morgantown West Virginia USA

5. Division of Bariatric Surgery; West Virginia University Health Sciences Center; Morgantown West Virginia USA

6. Division of Vascular Surgery; West Virginia University Health Sciences Center; Morgantown West Virginia USA

7. Department of Physiology and Pharmacology; West Virginia University Health Sciences Center; Morgantown West Virginia USA

Funder

National Institutes of Health

American Heart Association

NIH

Publisher

Wiley

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Molecular Biology,Physiology

Reference46 articles.

1. Pioglitazone prevents capillary rarefaction in streptozotocin-diabetic rats independently of glucose control and vascular endothelial growth factor expression;Ashoff;J Vasc Res,2012

2. Overview of epidemiology and contribution of obesity to cardiovascular disease;Bastien;Prog Cardiovasc Dis,2014

3. The Zucker-fatty rat: a review;Bray;Fed Proc,1977

4. The ex vivo isolated skeletal microvessel preparation for investigation of vascular reactivity;Butcher;J Vis Exp,2012

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