A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase-Reference-Cited by-同舟云学术

A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

Published:2020-12-27 Issue: Volume: Page:
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Groom Sam¹²,Blum Nina K.³,Conibear Alexandra E.²,Disney Alexander¹,Hill Rob²⁴,Husbands Stephen M.¹,Li Yangmei⁵,Toll Lawrence⁶,Kliewer Andrea³^ORCID,Schulz Stefan³,Henderson Graeme²^ORCID,Kelly Eamonn²^ORCID,Bailey Chris P.¹^ORCID

Affiliation:

1. Department of Pharmacy and Pharmacology University of Bath Bath UK

2. School of Physiology, Pharmacology and Neuroscience University of Bristol Bristol UK

3. Institute of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena Germany

4. School of Life Sciences University of Nottingham Nottingham UK

5. Department of Drug Discovery and Biomedical Sciences University of South Carolina Columbia South Carolina USA

6. Department of Biomedical Science, Charles E. Schmidt College of Medicine Florida Atlantic University Boca Raton Florida USA

Funder

British Pharmacological Society

National Institute on Drug Abuse

Korea National Institute of Health

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15334

Reference55 articles.

1. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

2. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

3. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

4. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

5. Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

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