Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease

Author:

Mirzaei Nazanin1,Mota Bibiana C.1,Birch Amy M.1,Davis Nicola1,Romero‐Molina Carmen1,Katsouri Loukia1,Palmer Emily O.C.1,Golbano Arantxa2,Riggall Laura J.1,Nagy Istvan3,Tyacke Robin1,Nutt David J.1,Sastre Magdalena1

Affiliation:

1. Department of Brain Sciences Imperial College London, Hammersmith Hospital London UK

2. Institute of Neurosciences Universitat Autònoma de Barcelona Barcelona Spain

3. Department of Surgery and Cancer Imperial College London, Chelsea and Westminster Hospital London UK

Funder

Dunhill Medical Trust

Imperial College London

Edmond J. Safra Philanthropic Foundation

Publisher

Wiley

Subject

Pharmacology

Reference63 articles.

1. Bicyclic α‐iminophosphonates as high affinity imidazoline I2 receptor ligands for Alzheimer's disease;Abás S.;Journal of Medicinal Chemistry,2020

2. LSL 60101, a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration

3. Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes

4. The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors;Alexander S. P. H.;British Journal of Pharmacology,2019

5. The Concise Guide to PHARMACOLOGY 2019/20: Ion channels;Alexander S. P. H.;British Journal of Pharmacology,2019

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