The albumin-bilirubin grade improves hepatic reserve estimation post-sorafenib failure: implications for drug development

Author:

Pinato D. J.1,Yen C.1,Bettinger D.2,Ramaswami R.1,Arizumi T.3,Ward C.1,Pirisi M.45,Burlone M. E.4,Thimme R.2,Kudo M.3,Sharma R.1

Affiliation:

1. Department of Surgery & Cancer; Hammersmith Campus of Imperial College London; London UK

2. Department of Medicine II; University Hospital Freiburg; Freiburg Germany

3. Department of Gastroenterology and Hepatology; Kindai University School of Medicine; Osaka Japan

4. Department of Translational Medicine; Università degli Studi del Piemonte Orientale “A. Avogadro”; Novara Italy

5. Interdisciplinary Research Center of Autoimmune Diseases; Università degli Studi del Piemonte Orientale “A. Avogadro”; Novara Italy

Funder

Academy of Medical Sciences

National Institute for Health Research

Albert-Ludwigs-Universität Freiburg

Wellcome Trust

Medical Research Council

British Heart Foundation

Arthritis Research UK

Royal College of Physicians

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference36 articles.

1. Assessment of prognosis of cirrhosis;Durand;Semin Liver Dis,2008

2. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis;Worns;J Clin Gastroenterol,2009

3. Sorafenib in the treatment of hepatocellular carcinoma: a multi-centre real-world study;Doyle;Scand J Gastroenterol,2016

4. Comparative dosing and efficacy of sorafenib in hepatocellular cancer patients with varying liver dysfunction;Al-Rajabi;J Gastrointest Oncol,2015

5. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma and Child-Pugh A or B cirrhosis;Federico;Oncol Lett,2015

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