Anakinra for palmoplantar pustulosis: results from a randomized, double‐blind, multicentre, two‐staged, adaptive placebo‐controlled trial (APRICOT)*

Author:

Cro S.1ORCID,Cornelius V.R.1,Pink A.E.2,Wilson R.2,Pushpa‐Rajah A.2,Patel P.2,Abdul‐Wahab A.3,August S.4,Azad J.5,Becher G.6,Chapman A.7,Dunnill G.8,Ferguson A.D.9,Fogo A.10,Ghaffar S.A.11,Ingram J.R.12ORCID,Kavakleiva S.13,Ladoyanni E.14,Leman J.A.15,Macbeth A.E.16,Makrygeorgou A.6,Parslew R.17,Ryan A.J.18,Sharma A.19,Shipman A.R.20ORCID,Sinclair C.21,Wachsmuth R.22,Woolf R.T.2,Wright A.23,McAteer H.24,Barker J.N.W.N.25,Burden A.D.26,Griffiths C.E.M.27ORCID,Reynolds N.J.28,Warren R.B.29,Lachmann H.J.29,Capon F.30ORCID,Smith C.H.2ORCID,Altamura Davide,Piguet Vincent,Verdolini Roberto,Wallace Marc,Sundararaj Kavitha,Arujuna Nisha,Fleming Charlotte,Lamb Ruth,Dodds Jacqueline,Baryschpolec Sonia,Cooper Hywel,

Affiliation:

1. Imperial Clinical Trials Unit Imperial College London London W12 7RH UK

2. St John’s Institute of Dermatology Guy’s Hospital Guy’s and St Thomas’ NHS Foundation Trust London SE1 9RT UK

3. St George’s University Hospitals NHS Foundation Trust London SW17 0QT UK

4. Poole Hospital NHS Foundation Trust University Hospitals Dorset Poole BH15 2JB UK

5. South Tees Hospitals NHS Foundation Trust Middlesbrough TS4 3BW UK

6. West Glasgow Ambulatory Care Hospital Glasgow G3 8SJ UK

7. Homerton University Hospital London E9 6SR UK

8. Bristol Royal Infirmary Bristol BS2 8HW UK

9. University Hospitals of Derby and Burton NHS Foundation Trust Derby DE22 3NE UK

10. Kingston Hospital Kingston upon Thames KT2 7QB UK

11. Ninewells Hospital and Medical School Dundee DD1 9SY UK

12. Division of Infection and Immunity School of Medicine Cardiff University University Hospital of Wales Cardiff CF14 4XN UK

13. Royal Lancaster Infirmary Lancaster LA1 4RP UK

14. Russells Hall Hospital Dudley DY1 2HQ UK

15. Kings Park Hospital Stirling FK7 9JH UK

16. Norfolk and Norwich University Hospitals NHS Foundation Trust Norwich NR4 7UY UK

17. Liverpool University Hospitals NHS Foundation Trust Liverpool L9 7AL UK

18. King’s College Hospital London SE5 9RS UK

19. Nottingham University Hospitals NHS Trust Nottingham NG7 2UH UK

20. Portsmouth Hospitals Universities NHS Trust St Mary’s Community Health Campus Portsmouth PO3 6AD UK

21. Broomfield Hospital Chelmsford CM1 7ET UK

22. Royal Devon and Exeter NHS Foundation Trust Exeter EX2 5DW UK

23. Bradford Teaching Hospitals NHS Foundation Trust Bradford BD9 6RJ UK

24. The Psoriasis Association Northampton NN4 7BF UK

25. St John’s Institute of Dermatology School of Basic and Medical Biosciences Faculty of Life Sciences and Medicine King’s College London London SE1 9RT UK

26. Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow G12 8TA UK

27. Dermatology Centre Salford Royal NHS Foundation Trust University of Manchester NIHR Manchester Biomedical Research Centre Manchester M6 8HD UK

28. Institute of Translational and Clinical Medicine Medical School University of Newcastle Department of Dermatology Royal Victoria Infirmary and NIHR Newcastle Biomedical Research Centre Newcastle Hospitals NHS Foundation Trust Newcastle upon Tyne NE2 4HH UK

29. National Amyloidosis Centre University College London London NW3 2PF UK

30. Department of Medical and Molecular Genetics King’s College London London SE1 9RT UK

Funder

Efficacy and Mechanism Evaluation Programme

Swedish Orphan Biovitrum

Publisher

Wiley

Subject

Dermatology

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