Synchronous occurrence of primary cutaneous B‐cell lymphoma and cutaneous Rosai–Dorfman disease in distinct lesions: A unique association

Author:

Roccuzzo Gabriele1ORCID,Avallone Gianluca1,Cavallo Francesco1,Mastorino Luca1,Conti Luca2,Fava Paolo1,Tomasini Carlo3ORCID,Ribero Simone1,Quaglino Pietro1

Affiliation:

1. Department of Medical Sciences, Section of Dermatology University of Turin Turin Italy

2. Department of Medical Sciences, Section of Surgical Pathology University of Turin Turin Italy

3. Department of Clinical‐Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy

Abstract

AbstractRosai–Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare subtype of reactive histiocytosis which is seldom associated with Hodgkin's and non‐Hodgkin's lymphomas. To date, the coexistence in the same patient of extra nodal SHML and primary cutaneous B‐cell lymphoma (PCBCL) has been reported in the literature, as metachronous diagnosis in the anatomical area of the original PCBCL or synchronous occurrence in the same lesions. However, no data have been published as for synchronous occurrence of the two pathological entities in distinct anatomical sites. Herein, we report the first ever described synchronous occurrence of PCBCL and SHML, detected in distinct lesions, affecting the same patient. The complete resolution of the patient's PCBCL after rituximab treatment and the concomitant regression of SHML suggest that this clinically benign reactive histiocytic proliferation, potentially triggered by the lymphoma microenvironment itself, may take place not only in the site of the PCBCL lesion, but also in other distant areas not directly affected by the primary cutaneous lymphoma.

Publisher

Wiley

Subject

Dermatology,Histology,Pathology and Forensic Medicine

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