Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions

Author:

Amstutz Ursula1234,Shear Neil H.5,Rieder Michael J.6,Hwang Soomi7,Fung Vincent789,Nakamura Hidefumi10,Connolly Mary B.311,Ito Shinya12,Carleton Bruce C.123,

Affiliation:

1. Division of Translational Therapeutics; Department of Pediatrics; University of British Columbia; Vancouver British Columbia Canada

2. Pharmaceutical Outcomes Programme; British Columbia Children's Hospital; Vancouver British Columbia Canada

3. Child and Family Research Institute; Vancouver British Columbia Canada

4. Department of Clinical Chemistry; University of Bern and Inselspital University Hospital; Bern Switzerland

5. Dermatology, Clinical Pharmacology and Toxicology; Department of Medicine; Sunnybrook Health Sciences Centre; University of Toronto; Toronto ON Canada

6. Clinical Pharmacology; Departments of Medicine, Physiology, Pharmacology and Pediatrics; Schulich School of Medicine and Dentistry; University of Western Ontario; London ON Canada

7. Faculty of Pharmaceutical Sciences; University of British Columbia; Vancouver British Columbia Canada

8. Prohealth Clinical Research Centre; Vancouver British Columbia Canada

9. Departments of Family Medicine and Pathology and Laboratory Medicine; Faculty of Medicine; University of British Columbia; Vancouver British Columbia Canada

10. Division for Clinical Trials; Clinical Research Center; National Center for Child Health and Development; Tokyo Japan

11. Division of Neurology; Department of Pediatrics; British Columbia Children's Hospital and University of British Columbia; Vancouver British Columbia Canada

12. Division of Clinical Pharmacology and Toxicology; Department of Pediatrics; The Hospital for Sick Children; University of Toronto; Toronto ON Canada

Funder

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference60 articles.

1. Novartis Pharmaceuticals Corporation Tegretol ® [prescribing information] http://www.pharma.us.novartis.com/product/pi/pdf/tegretol.pdf

2. Novartis Pharmaceuticals Canada Inc TEGRETOL [Product Monograph] http://www.hc-sc.gc.ca/dhp-mps/prodpharma/databasdon/index-eng.php

3. National Clinical Guideline Centre The Epilepsies: The Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care (Clinical Guideline CG137, January 2012) http://publications.nice.org.uk/the-epilepsies-the-diagnosis-and-management-of-the-epilepsies-in-adults-and-children-in-primary-and-cg137

4. Canadian Agency for Drugs and Technologies in Health Pharmacological Treatments in Patients with Epilepsy: Guidelines http://www.cadth.ca/media/pdf/htis/April-2011/K0338_Guidelines_for_Treatment_of_Epilepsy_final.pdf

5. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024;Ambrosio;Neurochem Res,2002

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