Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice-Reference-Cited by-同舟云学术

Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice

Published:2022-02-04 Issue: Volume: Page:
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Beamer Edward¹²,Morgan James¹³,Alves Mariana¹,Menéndez Méndez Aida¹,Morris Gareth¹⁴,Zimmer Béla⁵,Conte Giorgia¹,Diego‐Garcia Laura¹,Alarcón‐Vila Cristina⁶,Yiu Ng Nico Ka¹,Madden Stephen⁷,Calzaferri Francesco⁸^ORCID,Ríos Cristóbal⁸⁹,García Antonio G.⁸⁹,Hamacher Michael¹⁰,Dinkel Klaus¹¹,Pelegrín Pablo⁶¹²^ORCID,Henshall David C.¹⁴,Nicke Annette⁵^ORCID,Engel Tobias¹⁴^ORCID

Affiliation:

1. Department of Physiology and Medical Physics RCSI University of Medicine and Health Sciences Dublin Ireland

2. School of Science and Technology Nottingham Trent University Nottingham UK

3. Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK

4. FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases RCSI University of Medicine and Health Sciences Dublin Ireland

5. Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine Ludwig‐Maximilians‐Universität München Munich Germany

6. Instituto Murciano de Investigación Biosanitaria (IMIB‐Arrixaca) Hospital Clínico Universitario Virgen de la Arrixaca Murcia Spain

7. Data Science Centre RCSI University of Medicine and Health Sciences Dublin Ireland

8. Instituto‐Fundación Teofilo Hernando and Departamento de Farmacologia, Facultad de Medicina Universidad Autonoma de Madrid Madrid Spain

9. Instituto de Investigacion Sanitaria Hospital Universitario de La Princesa Madrid Spain

10. Affectis Pharmaceuticals AG Dortmund Germany

11. Lead Discovery Center GmbH Dortmund Germany

12. Department of Biochemistry and Molecular Biology B and Immunology University of Murcia Murcia Spain

Funder

European Research Council

Fundación Séneca

Deutsche Forschungsgemeinschaft

Irish Research Council

Science Foundation Ireland

Health Research Board

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15785

Reference63 articles.

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4. Context‐specific switch from anti‐ to pro‐epileptogenic function of the P2Y1 receptor in experimental epilepsy;Alves M.;The Journal of Neuroscience,2019

5. P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy;Amhaoul H.;Neuropharmacology,2016

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