Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats

Author:

Zhang Gaoxiao1,Zhang Tao1,Li Ning1,Wu Liangmiao1,Gu Jianbo12,Li Cuimei2,Zhao Chen1,Liu Wei2,Shan Luchen1,Yu Pei1,Yang Xifei3,Tang Yaohui4,Yang Guo-Yuan4,Wang Yuqiang1,Sun Yewei1,Zhang Zaijun1ORCID

Affiliation:

1. Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases; Jinan University College of Pharmacy; Guangzhou China

2. Guangzhou Magpie Pharmaceuticals Co., LTD.; Guangzhou China

3. Key Laboratory of Modern Toxicology of Shenzhen, Center for Disease Control and Prevention; Shenzhen China

4. Neuroscience and Neuroengineering Center, Med-X Research Institute and School of Biomedical Engineering; Shanghai Jiao Tong University; Shanghai China

Funder

Fundamental Research Funds for the Central Universities

Science and Technology Program of Guangzhou

National Natural Science Foundation of China

GD-HK Cooperative Project

Scientific Projects of Guangdong Province

Publisher

Wiley

Subject

Pharmacology

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