Granulomatous meningoencephalitis and blindness associated with Mycobacterium tuberculosis complex infection in a senile female chimpanzee (Pan troglodytes)

Author:

dos Santos Daniel Oliveira1ORCID,de Paula Nayara Ferreira1ORCID,de Carvalho Thaynara Parente1ORCID,dos Reis de Souza Lucas1ORCID,Tinoco Herlandes Penha2ORCID,Coelho Carlyle Mendes2ORCID,Sousa Ana Augusta3,Filho Paulo Martins Soares4ORCID,Ferreira Luciana Rabello4ORCID,da Paixão Tatiane Alves5ORCID,Oliveira Ayisa Rodrigues1ORCID,Santos Renato Lima1ORCID

Affiliation:

1. Escola de Veterinária Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil

2. Fundação de Parques Municipais e Zoobotânica Belo Horizonte Minas Gerais Brazil

3. Visiovet Diagnóstico Veterinário Belo Horizonte Minas Gerais Brazil

4. Laboratório Federal de Defesa—LFDA/MAPA Pedro Leopoldo Minas Gerais Brazil

5. Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil

Abstract

AbstractA 40‐year old female chimpanzee (Pan troglodytes) developed hyporexia, weight loss, followed by progressive and complete blindness. Tomography demonstrated an intracranial mass in the rostroventral brain involving the optic chiasm, with a presumptive diagnosis of neoplasm. However, histopathology revealed a granulomatous meningoencephalitis, and tissue samples tested positive for Mycobacterium tuberculosis.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

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