Prokinetics‐safety and efficacy: The European Society of Neurogastroenterology and Motility/The American Neurogastroenterology and Motility Society expert review-Reference-Cited by-同舟云学术

Prokinetics‐safety and efficacy: The European Society of Neurogastroenterology and Motility/The American Neurogastroenterology and Motility Society expert review

Published:2024-03-10 Issue:5 Volume:36 Page:
ISSN:1350-1925
Container-title:Neurogastroenterology & Motility
language:en
Short-container-title:Neurogastroenterology Motil

Author:

Bor Serhat¹^ORCID,Kalkan İsmail H.²^ORCID,Savarino Edoardo³^ORCID,Rao Satish⁴^ORCID,Tack Jan⁵^ORCID,Pasricha Jay⁶,Cangemi David⁷^ORCID,Schol Jolien⁸^ORCID,Karunaratne Tennekoon⁹^ORCID,Ghisa Matteo¹⁰^ORCID,Ahuja Nitin K.¹¹^ORCID,Lacy Brian¹²^ORCID

Affiliation:

1. Division of Gastroenterology, School of Medicine & Ege Reflux Study Group Ege University Izmir Turkey

2. Department of Gastroenterology, School of Medicine TOBB University of Economics and Technology Ankara Turkey

3. Gastroenterology Unit Azienda Ospedale Università di Padova (AOUP) Padua Italy

4. Division of Gastroenterology and Hepatology, Digestive Health Center Augusta University Augusta Georgia USA

5. Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA) KU Leuven Leuven Belgium

6. Division of Gastroenterology and Hepatology Johns Hopkins University Baltimore Maryland USA

7. Division of Gastroenterology & Hepatology Mayo Clinic Jacksonville Florida USA

8. Translational Research Center for Gastrointestinal Disorders University of Leuven Leuven Belgium

9. Division of Gastroenterology/Hepatology, Medical College of Georgia Augusta University Augusta Georgia USA

10. Digestive Endoscopy Unit, Division of Gastroenterology Padua University Hospital Padua Italy

11. Division of Gastroenterology, Penn Medicine Philadelphia Pennsylvania USA

12. Division of Gastroenterology and Hepatology Mayo Clinic Jacksonville Florida USA

Abstract

AbstractBackgroundProkinetics are a class of pharmacological drugs designed to improve gastrointestinal (GI) motility, either regionally or across the whole gut. Each drug has its merits and drawbacks, and based on current evidence as high‐quality studies are limited, we have no clear recommendation on one class or other. However, there remains a large unmet need for both regionally selective and/or globally acting prokinetic drugs that work primarily intraluminally and are safe and without systemic side effects.PurposeHere, we describe the strengths and weaknesses of six classes of prokinetic drugs, including their pharmacokinetic properties, efficacy, safety and tolerability and potential indications.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.14774

Reference333 articles.

1. Why do we have so few effective drugs for irritable bowel syndrome? A European perspective

2. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response

3. A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation

4. Comparison of pyridostigmine and bisacodyl in the treatment of refractory chronic constipation;Soufi‐Afshar I;Caspian J Intern Med,2016

5. Studio in doppia cecità tra neostigmina en versus placebo nell'ileo paralitico conseguente ad interventi chirurgici [A double‐blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions];Orlando E;Minerva Chir,1994