Opium tincture versus methadone for opioid agonist treatment: a randomized controlled trial

Author:

Nikoo Mohammadali1ORCID,Kianpoor Kiana1,Nikoo Nooshin2,Javidanbardan Sanam2,Kazemi Alireza1,Choi Fiona1,Vogel Marc34ORCID,Gholami Ali5,Tavakoli Saeed6,Wong James S. H.17ORCID,Moazen‐Zadeh Ehsan8ORCID,Givaki Reza9,Jazani Majid10,Mohammadian Fatemeh10,Moghaddam Nader Markazi11,Schütz Christian1,Jang Kerry1,Akhondzadeh Shahin12,Krausz Michael13

Affiliation:

1. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine University of British Columbia Vancouver BC Canada

2. Faculty of Medicine University of British Columbia Vancouver BC Canada

3. Division of Substance Use Disorders, Psychiatric Services of Thurgovia Münsterlingen Switzerland

4. Division of Substance Use Disorders University of Basel Psychiatric Clinics Basel Switzerland

5. Kian Methadone Maintenance Treatment Clinic, Private Practice Sari Mazandaran Iran

6. Rooz‐e‐No, Methadone Maintenance Treatment Clinic (Private Practice) Shiraz Fars Iran

7. Complex Pain and Addiction Consult Service Vancouver General Hospital Vancouver BC Canada

8. Addiction Institute of Mount Sinai, Department of Psychiatry Icahn School of Medicine at Mount Sinai NY USA

9. Psychosomatic Research Center Isfahan University of Medical Sciences Isfahan Iran

10. Sales, Marketing, Export and Medical Department, Darou Pakhsh Pharmaceutical Manufacturing Company Tehran Iran

11. Department of Health Management and Economics, School of Medicine AJA University of Medical Sciences Tehran Iran

12. Psychiatric Research Center, Roozbeh Hospital, Department of Psychiatry, Faculty of Medicine Tehran University of Medical Sciences Iran

13. Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, Faculty of Medicine University of British Columbia Vancouver BC Canada

Funder

Aja University of Medical Sciences

Canadian Institutes of Health Research

Iran National Science Foundation

Tehran University of Medical Sciences and Health Services

Publisher

Wiley

Subject

Psychiatry and Mental health,Medicine (miscellaneous)

Reference31 articles.

1. DailyMed.Label: Opium Tincture Deodorized—morphine tincture 2017. [accessed 2022 Aug 25] Available at:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2a5697a-cc41-4cf1-b3a8-59b0268740d7

2. United Nations Office on Drugs and Crime.The Opium Alkaloids 1953. [accessed 2022 Aug 25] Available at:https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1953-01-01_3_page005.html

3. Use of topical rectal therapy to preserve the rectum in surgery of ulcerative colitis

4. Diluted tincture of opium (DTO) and phenobarbital versus DTO alone for neonatal opiate withdrawal in term infants

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