Accelerated cognitive decline after the COVID‐19 pandemic in a community population of older persons with cognitive impairment: A 4‐year time series analysis in the Tokyo Metropolis area

Author:

Matsui Toshifumi12ORCID,Mitsuma Sayuri12,Nagata Akane1,Matsushita Sachio3,Asahi Toshiomi4

Affiliation:

1. Medical Center for Dementia in the Northeastern Wards of Tokyo Metropolis Oouchi Hospital, Heisei Medical Welfare Group Tokyo Japan

2. Department of Geriatric Medicine Kyorin University School of Medicine Tokyo Japan

3. Medical Center for Dementia in Kanagawa Prefecture National Hospital Organization, Kurihama Alcoholism Center Kanagawa Japan

4. Medical Center for Dementia in Chiba Prefecture Asahi Neurology and Rehabilitation Hospital Matsudo Japan

Abstract

AimThe coronavirus disease 2019 (COVID‐19) pandemic has led to lifestyle restrictions and might be associated with long‐term changes in cognitive function. The aim of the present study was to elucidate the overall effect of the COVID‐19 pandemic on the cognitive trajectory of a cohort of patients with cognitive impairment.MethodsWe enrolled 160 patients who had been making regular visits to a medical center for dementia. Cognitive function was assessed based on changes in scores on the Mini‐Mental State Examination before and during the COVID‐19 pandemic throughout a 4‐year period. The trajectory of cognitive decline was determined by carrying out a time series analysis using a state‐space model.ResultsCrude analysis showed that the Mini‐Mental State Examination scores decreased from 20.9 ± 4.4 points (mean ± SD) at the time of the initial cognitive assessments to 17.5 ± 5.6 points at the time of the final assessments, and the decline rate was 1.15 ± 1.78 points per year (P < 0.0001). The time series analysis showed an accelerated cognitive trajectory after the COVID‐19 outbreak, and the average decline in the Mini‐Mental State Examination scores was 0.46 points (95% confidence interval 0.034–0.91) per year before the COVID‐19 pandemic, and a steeper decline of 1.87 points (95% confidence interval 1.34–2.67) per year after the outbreak.ConclusionsThe COVID‐19 pandemic accelerated the rate of cognitive decline in patients with cognitive impairment fourfold in comparison with before the pandemic. Specific strategies designed for cognitively older people in the “new normal” will reconcile both requirements, reducing the risk of infection, and maintaining their physical and psychological well‐being. Geriatr Gerontol Int 2023; 23: 200–204.

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

General Medicine

Reference27 articles.

1. Visualizing the data: information on COVID‐19 infections.2022.https://covid19.mhlw.go.jp/extensions/public/en/index.html. Accessed May 3 2022.

2. Providing Simultaneous COVID-19–sensitive and Dementia-Sensitive Care as We Transition from Crisis Care to Ongoing Care

3. Instrumental Activities of Daily Living (iADL) Limitations in Europe: An Assessment of SHARE Data

4. The community-based integrated care system in Japan: Health care and nursing care challenges posed by super-aged society

5. Dementia ‐ Japan Health Policy NOW 2nd edition.http://japanhpn.org/en/dementia-1/. Accessed May 3 2022.

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3