Secukinumab significantly reduces inflammation but only mildly improves scaling in four cases of autosomal recessive congenital ichthyosis-Reference-Cited by-同舟云学术

Secukinumab significantly reduces inflammation but only mildly improves scaling in four cases of autosomal recessive congenital ichthyosis

Published:2022-12-01 Issue:12 Volume:47 Page:2288-2290
ISSN:1365-2230
Container-title:Clinical and Experimental Dermatology
language:en
Short-container-title:

Author:

Subramani Dharshini¹,Sardana Gitika²,Kothari Rohit¹,Gupta Aayush¹^ORCID

Affiliation:

1. Department of Dermatology, Dr D. Y. Patil Medical College, Hospital and Research Centre Dr D. Y. Patil Vidyapeeth Pimpri Pune Maharashtra 411018 India

2. Department of Paediatrics, Dr D. Y. Patil Medical College, Hospital and Research Centre Dr D. Y. Patil Vidyapeeth Pimpri Pune Maharashtra 411018 India

Abstract

Abstract Using the psoriasis regimen, administration of secukinumab 150 mg led to a significant reduction in inflammation and some reduction in scaling in four paediatric cases of autosomal recessive congenital ichthyosis.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ced.15373

Reference6 articles.

1. An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis;Paller;J Allergy Clin Immunol,2017

2. The major orphan forms of ichthyosis are characterized by systemic T-cell activation and Th-17/Tc-17/Th-22/Tc-22 polarization in blood;Czarnowicki;J Investig Dermatol,2018

3. The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: immunophenotyping and response to ustekinumab;Paller;J Am Acad Dermatol,2018

4. Autosomal recessive congenital ichthyosis due to homozygous variants in NIPAL4 with a dramatic response to ustekinumab;Poulton;Pediatr Dermatol,2019

5. Profiling immune expression to consider repurposing therapeutics for the ichthyoses;Paller;J Investig Dermatol,2019

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1. Secukinumab therapy for paediatric patients with various phenotypes of congenital ichthyosis;Clinical and Experimental Dermatology;2024-03-12

2. Biologics for inherited disorders of keratinisation: A systematic review;Australasian Journal of Dermatology;2023-12-21

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