Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria

Author:

Belluco Sara1ORCID,Marano Giuseppe2,Lurier Thibaut34,Avallone Giancarlo5ORCID,Brachelente Chiara6,Di Palma Stefano7,Rasotto Roberta8,Baiker Kerstin9,Beineke Andreas10,Oevermann Anna11,Seehusen Frauke12,de Sant'Ana Fabiano José Ferreira13ORCID,Boracchi Patrizia2,Pumarola Martí14,Mandara Maria Teresa15

Affiliation:

1. Université de Lyon, VetAgro Sup, ICE UPSP 2016.A104, Axe Cancérologie, Marcy l'Etoile Lyon France

2. Department of Biomedical and Clinical Sciences "L. Sacco" University of Milan Milan Italy

3. INRAE, VetAgro Sup, UMR EPIA Université Clermont Auvergne Saint‐Genès‐Champanelle France

4. INRAE, VetAgro Sup, UMR EPIA Université de Lyon Lyon France

5. Dipartimento di Scienze Mediche Veterinarie Università di Bologna Bologna Italy

6. Dipartimento di Medicina Veterinaria Università degli Studi di Perugia Perugia Italy

7. IDEXX Laboratories Wetherby UK

8. Diagnostic Pathology, Dick White Referrals, Station Farm Cambridgeshire UK

9. Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Science City University of Hong Kong Kowloon Hong Kong

10. Stiftung Tierärztliche Hochschule Hannover, Institut für Pathologie Hannover Germany

11. Division of Neurological Sciences, Vetsuisse Faculty University of Bern Bern Switzerland

12. Institute of Veterinary Pathology, Vetsuisse Faculty University of Zurich Zurich Switzerland

13. Laboratório de Diagnóstico Patológico Veterinário Universidade de Brasília Brasília Brazil

14. Dept Medicina i Cirurgia, Animals, Facultat de Veterinària Barcelona Spain

15. Laboratorio di Neuropatologia, Dip. di Medicina Veterinaria Università degli Studi di Perugia Perugia Italy

Abstract

AbstractCanine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter‐observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas following the human grading system alone or with the new guidelines. The inter‐observer agreement for histologic grade and each of the grading criteria (mitotic grade, invasion, spontaneous necrosis, macronucleoli, small cells, hypercellularity, pattern loss and anaplasia) was evaluated using the Fleiss kappa index. The diagnostic accuracy (sensitivity and specificity) was assessed by comparing the diagnoses obtained with the 2 grading systems with a consensus grade (considered the reference classification). The consensus histologic grade was obtained by agreement between 4 experienced veterinary neuropathologists following the guidelines. Compared with the human grading alone, the canine‐specific guidelines increased the inter‐observer agreement for: histologic grade (κ = 0.52); invasion (κ = 0.67); necrosis (κ = 0.62); small cells (κ = 0.36); pattern loss (κ = 0.49) and anaplasia (κ = 0.55). Mitotic grade agreement remained substantial (κ = 0.63). The guidelines improved the sensitivity in identifying grade 1 (95.6%) and the specificity in identifying grade 2 (96.2%) meningiomas. In conclusion, the new grading guidelines for canine meningiomas are associated with an overall improvement in the inter‐observer agreement and higher diagnostic accuracy in diagnosing grade 1 and grade 2 meningiomas.

Funder

VetAgro Sup

Publisher

Wiley

Subject

General Veterinary

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