Affiliation:
1. Department of Physiology LSU Health‐New Orleans New Orleans Louisiana USA
2. Alcohol & Drug Abuse Center of Excellence LSU Health‐New Orleans New Orleans Louisiana USA
3. Neuroscience Center of Excellence LSU Health‐New Orleans New Orleans Louisiana USA
4. Comprehensive Alcohol‐HIV/AIDS Research Center LSU Health‐New Orleans New Orleans Louisiana USA
Abstract
AbstractBackgroundAlthough a large percentage of chronic pain patients consume alcohol to manage their pain, there is a significant gap in knowledge regarding the mechanisms underlying the antinociceptive effects of alcohol.MethodsTo determine the longitudinal analgesic effects of alcohol, we utilized the complete Freund's adjuvant (CFA) model of inflammatory pain in adult female and male Wistar rats. Both somatic and negative motivational aspects of pain were measured using the electronic von Frey (mechanical nociception) system, thermal probe test (thermal nociception), and mechanical conflict avoidance task (pain avoidance‐like behavior). Tests were conducted at baseline and 1 and 3 weeks following intraplantar CFA or saline administration. At both time points post‐CFA, animals were treated with each of three doses of alcohol (intraperitoneal; 0, 0.5, and 1.0 g/kg) over separate days in a Latin square design.ResultsAlcohol produced dose‐dependent mechanical analgesia and antihyperalgesia in females but only antihyperalgesia in males. Although alcohol continued to attenuate CFA‐induced decreases in both thermal and mechanical nociceptive thresholds between 1 and 3 weeks post‐CFA, it appeared less effective at increasing thresholds 3 weeks after CFA induction.ConclusionsThese data suggest that individuals may develop tolerance to alcohol's ability to alleviate both somatic and negative motivational symptoms of chronic pain over time. We also discovered sex‐specific neuroadaptations in protein kinase A‐dependent phosphorylation of GluR1 subunits and extracellular signal‐regulated kinase (ERK 1/2) phosphorylation in nociceptive brain centers of animals receiving an alcohol challenge 1 week post‐CFA. Together, these findings illustrate a sex‐specific regulation of behavioral and neurobiological indices of persistent pain by alcohol.
Funder
National Institute of Neurological Disorders and Stroke
National Institute on Alcohol Abuse and Alcoholism
Cited by
1 articles.
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