Comparison of the effects on glycaemic control and β-cell function in newly diagnosed type 2 diabetes patients of treatment with exenatide, insulin or pioglitazone: a multicentre randomized parallel-group trial (the CONFIDENCE study)

Author:

Xu W.1,Bi Y.2,Sun Z.3,Li J.1,Guo L.4,Yang T.5,Wu G.6,Shi L.7,Feng Z.8,Qiu L.9,Li Q.10,Guo X.11,Luo Z.12,Lu J.13,Shan Z.14,Yang W.15,Ji Q.16,Yan L.17,Li H.18,Yu X.19,Li S.20,Zhou Z.21,Lv X.22,Liang Z.23,Lin S.24,Zeng L.1,Yan J.1,Ji L.25,Weng J.1

Affiliation:

1. Department of Endocrinology and Metabolism; Guangdong Provincial Key Laboratory of Diabetology; the Third Affiliated Hospital of Sun Yat-sen University; Guangzhou China

2. Department of Endocrinology; Drum Tower Hospital Affiliated to Nanjing University Medical School; Nanjing China

3. Department of Endocrinology; Zhongda Hospital; Institute of Diabetes; Medical School; Southeast University; Nanjing China

4. Department of Endocrinology; Beijing Hospital of the Ministry of Public Health; Beijing China

5. Department of Endocrinology; the First Affiliated Hospital of Nanjing Medical University; Nanjing China

6. Department of Endocrinology; the Affiliated Hospital of Guangdong Medical College; Zhanjiang China

7. Department of Endocrinology; Affiliated Hospital of Guiyang Medical College; Guizhou China

8. Department of Endocrinology; the First Affiliated Hospital; Chongqing Medical University; Chongqing China

9. Department of Endocrinology; the Affiliated Hospital of Inner Mongolia Medical University; Hohhot China

10. Department of Endocrinology; the Second Affiliated Hospital of Harbin Medical University; Harbin China

11. Department of Endocrinology; Peking University First Hospital; Beijing China

12. Department of Endocrinology; the First Affiliated Hospital of Guangxi Medical University; Nanning China

13. Department of Endocrinology; Chinese People's Liberation Army General Hospital; Beijing China

14. Department of Endocrinology; the First Affiliated Hospital of China Medical University; Shenyang China

15. Department of Endocrinology; China-Japan Friendship Hospital; Beijing China

16. Department of Endocrinology and Metabolism; Xijing Hospital affiliated to the Fourth Military Medical University; Xi'an China

17. Department of Endocrinology; Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Guangzhou China

18. Department of Endocrinology; the First Affiliated Hospital of Kunming Medical University; Kunming China

19. Department of Endocrinology; Tongji Hospital; Tongji Medical College of Huazhong University of Science and Technology; Wuhan China

20. Department of Endocrinology; Qingyuan People's Hospital; Qingyuan China

21. Diabetes Centre; Institute of Metabolism and Endocrinology; the Second Xiangya Hospital and Key Laboratory of Diabetes Immunology; Ministry of Education; Central South University; Changsha China

22. Department of Endocrinology; General Hospital of Beijing Military Region; Beijing China

23. Department of Endocrinology; First Affiliated Hospital of Shenzhen University; Shenzhen China

24. Department of Endocrinology; the First Affiliated Hospital; Shantou University Medical College; Shantou China

25. Department of Endocrinology; Peking University People's Hospital; Beijing China

Funder

Ministry of Health of the People's Republic of China

National Science Fund

Eli Lilly and Co.

Amylin Pharmaceuticals, Inc.

Bristol-Myers Squibb

Astra Zeneca

Publisher

Wiley

Subject

Internal Medicine

Reference32 articles.

1. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes;Kahn;Diabetologia,2003

2. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants;Danaei;Lancet,2011

3. Standards of Medical Care in Diabetes-2013;American Diabetes Association;Diabetes Care,2013

4. Clinical Practice Guidelines: pharmacologic management of Type 2 diabetes;Committee;Can J Diabetes,2013

5. China guideline for type 2 diabetes (2010 edition);Chinese Diabetes Society;Chin J Diabetes,2012

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