Alginate‐microencapsulation of human stem cell–derived β cells with CXCL 12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

Author:

Alagpulinsa David A.1,Cao Jenny J. L.12,Driscoll Riley K.13,Sîrbulescu Ruxandra F.1,Penson Madeline F. E.1,Sremac Marinko1,Engquist Elise N.4,Brauns Timothy A.1,Markmann James F.5,Melton Douglas A.4,Poznansky Mark C.1

Affiliation:

1. Vaccine and Immunotherapy Center Massachusetts General Hospital and Harvard Medical School Boston Massachusetts

2. Department of Pathology and School of Clinical Medicine University of Cambridge Cambridge UK

3. Department of Microbiology and Molecular Biology Brigham Young University Provo Utah

4. Department of Stem Cell and Regenerative Biology Harvard Stem Cell Institute Harvard University Cambridge Massachusetts

5. Department of Surgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference33 articles.

1. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid‐free immunosuppressive regimen;Shapiro AM;N Engl J Med,2000

2. Generation of functional human pancreatic beta cells in vitro;Pagliuca FW;Cell,2014

3. Generation of stem cell‐derived beta‐cells from patients with type 1 diabetes;Millman JR;Nat Commun,2016

4. Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells;Araki R;Nature,2013

5. Recurrent diabetes mellitus in the pancreas iso‐ and allograft. A light and electron microscopic and immunohistochemical analysis of four cases;Sibley RK;Lab Investig,1985

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