Targeting of prolamins by RNAi in bread wheat: effectiveness of seven silencing-fragment combinations for obtaining lines devoid of coeliac disease epitopes from highly immunogenic gliadins

Author:

Barro Francisco1,Iehisa Julio C. M.1,Giménez María J.1,García-Molina María D.1,Ozuna Carmen V.1,Comino Isabel2,Sousa Carolina2,Gil-Humanes Javier1

Affiliation:

1. Departamento de Mejora Genética; Instituto de Agricultura Sostenible (IAS); Consejo Superior de Investigaciones Científicas (CSIC); Córdoba Spain

2. Departamento de Microbiología y Parasitología; Facultad de Farmacia; Universidad de Sevilla; Sevilla Spain

Funder

Spanish Ministry of Economy and Competitiveness

Federación Española de Enfermedades Raras

Junta de Andalucía

Publisher

Wiley

Subject

Plant Science,Agronomy and Crop Science,Biotechnology

Reference42 articles.

1. Integration of genetic and immunological insights into a model of celiac disease pathogenesis;Abadie;Annu. Rev. Immunol.,2011

2. Transformation of the US bread wheat ‘Butte 86’ and silencing of omega-5 gliadin genes;Altenbach;GM Crops,2011

3. The gene space in wheat: the complete ɣ-gliadin gene family from the wheat cultivar Chinese Spring;Anderson;Funct. Integr. Genomics,2013

4. Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues;Arentz Hansen;Gastroenterology,2002

5. Protein composition and techno-functional properties of transgenic wheat with reduced α-gliadin content obtained by RNA interference;Becker;J. Appl. Bot. Food Qual.,2012

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