A drug screen with approved compounds identifies amlexanox as a novel Wnt/β‐catenin activator inducing lung epithelial organoid formation

Author:

Costa Rita12ORCID,Wagner Darcy E.13,Doryab Ali14ORCID,De Santis Martina M.13ORCID,Schorpp Kenji5,Rothenaigner Ina5,Lehmann Mareike1,Baarsma Hoeke A.16,Liu Xueping7,Schmid Otmar4,Campillos Monica7,Yildirim Ali Önder8,Hadian Kamyar5,Königshoff Melanie19ORCID

Affiliation:

1. Research Unit Lung Repair and Regeneration Helmholtz Zentrum München—German Research Center for Environmental Health, Ludwig Maximilian University of Munich, University Hospital Großhadern, Member of the German Center for Lung Research (DZL) Munich Germany

2. Institute of Virology Helmholtz Zentrum München—German Research Center for Environmental Health Neuherberg Germany

3. Department of Experimental Medical Sciences, Wallenberg Centre for Molecular Medicine, Faculty of Medicine, Stem Cell Centre Lund University Lund Sweden

4. Pulmonary Aerosol Delivery, Institute of Lung Biology and Disease, Comprehensive Pneumology Center Helmholtz Zentrum München—German Research Center for Environmental Health, Member of the German Center for Lung Research (DZL) Munich Germany

5. Assay Development and Screening Platform, Institute for Molecular Toxicology and Pharmacology Helmholtz Zentrum München—German Research Center for Environmental Health Neuherberg Germany

6. Department of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD University Medical Center Groningen, University of Groningen Groningen The Netherlands

7. Institute of Structural Biology Helmholtz Zentrum München—German Research Center for Environmental Health Neuherberg Germany

8. Immunopathology of COPD, Institute of Lung Biology and Disease, Comprehensive Pneumology Center Helmholtz Zentrum München—German Research Center for Environmental Health, Member of the German Center for Lung Research (DZL) Munich Germany

9. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA

Funder

Deutsche Zentrum für Lungenforschung

H2020 European Research Council

Publisher

Wiley

Subject

Pharmacology

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