Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor-Reference-Cited by-同舟云学术

Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor

Published:2021-07-23 Issue:4 Volume:98 Page:481-492
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Shin Woo Shik¹,Nguyen Megin E.¹,Bergstrom Alexander²,Jennings Isabella R.³,Crowder Michael W.²,Muthyala Ramaiah⁴,Sham Yuk Yin¹³

Affiliation:

1. Bioinformatics and Computational Biology Program University of Minnesota Minneapolis MN USA

2. Department of Chemistry and Biochemistry Miami University Oxford OH USA

3. Department of Integrative Biology and Physiology University of Minnesota Minneapolis MN USA

4. Department of Experimental & Clinical Pharmacology University of Minnesota Minneapolis MN USA

Funder

University of Minnesota

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.13912

Reference37 articles.

1. Interaction of Avibactam with Class B Metallo-β-Lactamases

2. Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-β-lactamase VIM-2

3. 264. Ionization constants of heterocyclic substances. Part II. Hydroxy-derivatives of nitrogenous six-membered ring-compounds

4. Molecular mechanisms of antibiotic resistance

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4. Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives;Journal of Medicinal Chemistry;2021-11-15