Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC

Author:

Michael Michael1,White Shane C2,Abdi Ehtesham34,Nott Louise5,Clingan Phillip6,Zimet Allan7,Button Peter8,Gregory Daniel9,Solomon Benjamin10,Dobrovic Alexander10,Do Hongdo10,Clarke Stephen11

Affiliation:

1. Division of Cancer Medicine; Peter MacCallum Cancer Centre; Melbourne Victoria Australia

2. Austin Health; Heidelberg Victoria Australia

3. The Tweed Hospital; Tweed Heads New South Wales Australia

4. Griffith University; Southport Queensland Australia

5. Royal Hobart Hospital; Hobart Tasmania Australia

6. Southern Medical Day Care Centre; Wollongong New South Wales Australia

7. Epworth Hospital; Richmond Victoria Australia

8. Infopeople, Pty Limited; Dee Why New South Wales Australia

9. Roche Products, Pty. Limited; Dee Why New South Wales Australia

10. Peter MacCallum Institute of Cancer Research; Melbourne Victoria Australia

11. Concord Repatriation General Hospital; Concord New South Wales Australia

Funder

Roche Products Pty Limited (Australia)

Publisher

Wiley

Subject

Oncology,General Medicine

Reference50 articles.

1. Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers;Gullick;Br Med Bull,1991

2. Molecular markers help characterize neuroendocrine lung tumors;Rusch;Ann Thorac Surg,1996

3. The role of amphiregulin in breast cancer;Salomon;Breast Cancer Res Treat,1995

4. Epidermal growth factor receptors in non-small cell lung cancer;Veale;Br J Cancer,1987

5. Enhancement of chemosensitivity and programmed cell death by tyrosine kinase inhibitors correlates with EGFR expression in non-small cell lung cancer cells;Lei;Anticancer Res,1999

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