Polymorphism of tumour necrosis factor-alpha (TNF-α) at position −308 in relation to ankylosing spondylitis-Reference-Cited by-同舟云学术

Polymorphism of tumour necrosis factor-alpha (TNF-α) at position −308 in relation to ankylosing spondylitis

Published:1994-07 Issue:1 Volume:97 Page:45-47
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

VERJANS G M G M¹,BRINKMAN B M N²,VAN DOORNIK C E M¹,KIJLSTRA A¹³,VERWEIJ C L²

Affiliation:

1. Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam

2. Department of Rheumatology, University of Leiden, Leiden

3. Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands

Abstract

SUMMARY In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-α, we investigated the association between AS and a single base polymorphism located at position – 308 of the TNF-α gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-α alleles was determined in 66 AS patients and 37 healthy controls. The TNF-α allele frequency was not significantly different between AS patients and controls.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/97/1/45/42209616/j.1365-2249.1994.tb06577.x.pdf

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