Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1-Reference-Cited by-同舟云学术

Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1

Published:1994-06 Issue:3 Volume:96 Page:422-426
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

AKATSUKA H¹²,IMANISHI K¹,INADA K³,YAMASHITA H³,YOSHIDA M³,UCHIYAMA T¹

Affiliation:

1. Department of Microbiology and Immunology, Tokyo Women's Medical College, Tokyo

2. Department of Internal Medicine II, Fukushima Medical College, Fukushima

3. Department of Bacteriology, Iwate Medical University, Iwate, Japan

Abstract

SUMMARY The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-α and TNF-β) upon stimulation with toxic shock syndrome toxin-l (TSST-I) and the requirement for MHC ctass II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was much higher than that of CD8+ T cells in TSST-1-induced production of TNF-α and TNF-β. The expression of MHC class II molecules on AC was required in the response.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/96/3/422/42209812/j.1365-2249.1994.tb06045.x.pdf

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