A role for IL-4 in immunologically mediated enteropathy-Reference-Cited by-同舟云学术

A role for IL-4 in immunologically mediated enteropathy

Published:1995-01 Issue:1 Volume:99 Page:65-69
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Mowat A MCI¹,Widmer M B²

Affiliation:

1. Department of Immunology, University of Glasgow, Western Infirmary, Glasgow, UK

2. Immunex Corporation, Seattle, WA, USA

Abstract

SUMMARY A number of clinical enteropathies are associated with a local cell-mediated immune (CMI) response, and experimental evidence indicates that cytokines are responsible for the intestinal pathology. We show here that depletion of IL-4 using MoAb or a soluble form of the IL-4 receptor (IL-4R) prevents the jejunal manifestations of a proliferative form of murine graft-versus-host reaction (GVHR) characterized by crypt hyperplasia and recruitment of intraepithelial lymphocytes (IEL). Depletion of IL-4 did not prevent the appearance of villus atrophy in a destructive model of GVHR, and had no effect on any indices of systemic immunity. These results indicate that IL-4 may play a selective role in mediating proliferative aspects of intestinal immunopathology, and suggest that this cytokine may provide a useful target for immunotherapy.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/99/1/65/42201946/j.1365-2249.1995.tb03473.x.pdf

Reference28 articles.

1. Models of immunologically driven small intestinal damage;Ferguson,1987

2. Intestinal graft-versus-host reactions in experimental animals;Mowat,1990

3. GvHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GvHR-induced mortality, medullary aplasia and enteropathy;Piguet;J Immunol,1985

4. Hypersensitivity reactions in the small intestine. VII. Induction of the intestinal phase of murine graft-versus-host reaction in mice by Lyt2− T cells activated by I-A alloantigens;Mowat;Transplantation,1986

5. Induction of intestinal graft-versus-host reactions across mutant major histocompatibility complex antigens by T lymphocyte subsets in mice. Transplantation in mice;Mowat;Transplantation,1989

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