Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients-Reference-Cited by-同舟云学术

Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients

Published:1995-11 Issue:2 Volume:102 Page:286-289
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Ferrer J M¹,Iglesias J¹,HernÁNdez M²,Matamoros N¹

Affiliation:

1. Immunology Section, Hospital Son ‘Dureta’, Palma de Mallorca, Spain

2. Immunology Section, Hospital Vall D'Hebrón, Barcelona, Spain

Abstract

SUMMARY The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of helper CD4 cells and their CD4 CD45RO subpopulation from CVI patients to secrete interleukins (IL-2 and IL-4) in response to mitogen stimulation. We found that CD4 and CD4 CD45RO cells from some patients secrete abnormal amounts of interleukins (in general low levels of IL-2 and high levels of IL-4) upon stimulation with pokeweed mitogen (PWM). These irregularities may contribute to the defective differentiation of B cells in these patients.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/102/2/286/42203107/j.1365-2249.1995.tb03779.x.pdf

Reference15 articles.

1. Cellular abnormalities in CVI;Spickett;Immunodef Rev,1990

2. Lymphocyte surface phenotype in common variable immunodeficiency;Spickell;Disease Markers,1992

3. Study of B and T cell phenotypes in blood from patients with common variable immunodeficiency (CVID);Farrant;Immunodeficiency,1994

4. B cell function in acquired “CVI” hypogammaglobulinemia: proliferative responses to lymphokines;Farrant;Clin Immunol Immunopathol,1989

5. Interleukin 10 and immune restoration in common variable immunodeficiency;Zielen;Lancet,1993

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Comparison of Post-Vaccination Cellular Immune Response in Patients with Common Variable Immune Deficiency;Vaccines;2024-07-25

2. CVID;Humoral Primary Immunodeficiencies;2018-12-30

3. Abnormality of regulatory T cells in common variable immunodeficiency;Cellular Immunology;2017-05

4. Autoimmunity and infection in common variable immunodeficiency (CVID);Autoimmunity Reviews;2016-09

5. The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency;Expert Review of Clinical Immunology;2015-12-14