The activation state of human intrahepatic lymphocytes

Author:

Tu Z1,Bozorgzadeh A1,Crispe I N2,Orloff M S1

Affiliation:

1. The Division of Solid Organ Transplantation and Hepatobiliary Surgery, Department of Surgery

2. the David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, USA

Abstract

Summary The immune tolerance induced by the liver as an allograft is difficult to reconcile with the evidence that the liver selectively accumulates activated T cells from the circulation. However, much of this information is based on murine liver lymphocytes that were isolated using enzymatic digestion. In the present study we made use of a novel resource, the lymphocytes isolated during the perfusion of living donor liver lobe prior to transplantation. These healthy human liver lymphocytes displayed surface markers indicating a high degree of activation of natural killer cells, CD56+ T cells, CD4+ T cells and CD8+ T cells. These properties were independent of enzymatic treatment or the details of cell isolation. We conclude that the healthy human liver is a site of intense immunological activity.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Reference30 articles.

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3. Portal vein administration of donor cells promotes peripheral allospecific hyporesponsiveness and graft tolerance;Yu;Surgery,1994

4. The effect of portal venous tolerance on the survival of small bowel allografts in the rat;Nakafusa;Transplantation,1993

5. Cytotoxic NK1.1 ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12;Hashimoto;J Immunol,1995

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