Human colostrum contains an activity that inhibits the production of IL-2-Reference-Cited by-同舟云学术

Human colostrum contains an activity that inhibits the production of IL-2

Published:1991-12 Issue:3 Volume:86 Page:520-524
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

HOOTON J W L¹,PABST H F²,SPADY D W²,PAETKAU V¹

Affiliation:

1. Department of Biochemistry, Walter MacKenzie Center, University of Alberta, Edmonton. Alberta, Canada

2. Department of Pediatrics, Walter MacKenzie Center, University of Alberta, Edmonton. Alberta, Canada

Abstract

SUMMARY The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor β.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/86/3/520/42213777/j.1365-2249.1991.tb02963.x.pdf

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