Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection

Author:

FEUCHT H E12,FELBER E2,GOKEL M J3,HILLEBRAND G4,NATTERMANN U4,BROCKMEYER C2,HELD E1,RIETHMÜLLER G2,LAND W5,ALBERT E6

Affiliation:

1. Medizinische Klinik Innenstadt

2. Institut f. Immunologie

3. Institut f. Pathologie

4. Nephrolog. Abtlg, Medizinische Klinik I

5. Abtlg. f. Transplantationschirurgie, Klinikum Groβhadern

6. Medizinische Kinderpoliklinik, University of Munich, Germany

Abstract

SUMMARY Complement activation in 73 renal transplant biopsies was investigated by indirect immunoperoxidase staining using MoAbs reactive with complement-split products. Intense deposition of complement fragments C4d and C3d in peritubular capillaries, indicating activation of the classical pathway, could be detected in the majority of transplanted kidneys with cell-mediated rejections. Abundant deposition of complement-split products was observed in 22 early biopsies from patients with high ‘immunological risk’ (i.e. previous, rejected transplants and/or circulating antibodies against HLA-antigens). Despite negative results in the crossmatch before transplantation and paucity of immunoglobulins in transplant biopsies, antibodies directed against endothelial cell antigens should be considered as a possible cause of classical complement activation.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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5. Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis;Berger;J. clin. Invest.,1989

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